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Rare adverse effects ( Intravenous aciclovir may cause reversible nephrotoxicity in up to 5% to 10% of patients because of precipitation of aciclovir crystals in the kidney.Aciclovir crystalline nephropathy is more common when aciclovir is given as a rapid infusion and in patients with dehydration and preexisting renal impairment.I know many friends who have been left with a “pink eye” after sharing mascara or using ancient mascara that’s been sitting in their make-up bags.’Finally, make-up brushes should not be shared because they gather bacteria including Staph aureus, and streptococcus.Intravenous aciclovir is effective to treat severe medical conditions caused by different species of the herpes virus family, including severe localized infections of herpes virus, severe genital herpes, chickenpox and herpetic encephalitis.Resistance to aciclovir is rare in people with healthy immune systems, but is more common (up to 10%) in people with immunodeficiencies on chronic antiviral prophylaxis (transplant recipients, people with acquired immunodeficiency syndrome due to HIV infection).Mechanisms of resistance in HSV include deficient viral thymidine kinase; and mutations to viral thymidine kinase or DNA polymerase, altering substrate sensitivity.
Meanwhile, mascara wands or eyeliner, whether tried out as testers on make-up stands or shared between friends, may lead to a nasty case of ‘pink-eye’.
However, this effect has not been clinically established and more studies need to be done to evaluate the true potential of this synergy.
Zidovudine: Although administered often with aciclovir in HIV patients, neurotoxicity has been reported in at least one patient who presented with extreme drowsiness and lethargy 30–60 days after receiving IV aciclovir; symptoms resolved when aciclovir was discontinued.
Other risks from shared make-up include salmonella and e.coli, as well as skin flare-ups from bacteria on other people’s faces.
Dr Amreen Bashir, a microbiologist from Aston University in Birmingham, said: ‘Most people would never consider sharing a toothbrush with a stranger, yet they happily use make-up testers.